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Article

Validation of an Ion Torrent Sequencing Platform for the Detection of Gene Mutations in Biopsy Specimens from Patients with Non-Small-Cell Lung Cancer.

PloS one - 1 Jan 2015

Fujita Shiro, Masago Katsuhiro, Takeshita Jumpei, Okuda Chiyuki, Otsuka Kyoko, Hata Akito, Kaji Reiko, Katakami Nobuyuki, Hirata Yukio

Abstract excerpt

BACKGROUND: Treatment for patients with advanced non-small cell lung cancer (NSCLC) is often determined by the presence of biomarkers that predict the response to agents targeting specific molecular pathways. Demands for multiplex analysis of the genes involved in the pathogenesis of NSCLC are increasing. METHODS: We validated the Ion Torrent Personal Genome Machine (PGM) system using the Ion AmpliSeq Cancer...

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Identifiers

PMID: 26076009
DOI: 10.1371/journal.pone.0130219
PMCID: PMC4467975

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