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Article

IgE and IgG epitope mapping by microarray peptide-immunoassay reveals the importance and diversity of the immune response to the IgG3 equine immunoglobulin.

Toxicon : official journal of the International Society on Toxinology - 1 Feb 2014

De-Simone Salvatore G, Napoleão-Pêgo Paloma, Teixeira-Pinto Luiz A L, Melgarejo Anibal R, Aguiar Aniesse S, Provance David W

Abstract excerpt

The presence of whole horse IgG in therapeutic snake antivenom preparations of high purity is a contamination that can cause IgE-mediated allergic reactions in patients. In this study, the immunodominant IgE and IgG-binding epitopes in horse heavy chain IgG3 were mapped using arrays of overlapping peptides synthesized directly onto activated cellulose membranes. Pooled human sera from patients with and without...

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Identifiers

PMID: 24334152
DOI: 10.1016/j.toxicon.2013.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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