Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues.

Abstract excerpt

We have used a quantitative immunoblot technique to analyze the Ab repertoire of IgG in the serum of healthy adults with a large panel of homologous and foreign Ags in tissue extracts. Densitometric patterns of reactivity of purified IgG with self-Ags exhibited striking homogeneity among individuals with regard to the protein bands that were recognized. Purified IgG showed higher levels of reactivity with...

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