Article
Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Sept 2013
Ihsan Awais, Wang Xu, Zhang Wei, Tu Honggang, Wang Yulian, Huang Lingli, Iqbal Zahid, Cheng Guyue, Pan Yuanhu, Liu Zhenli, Tan Ziqiang, Zhang Yuanyuan, Yuan Zonghui
Abstract excerpt
Quinocetone (QCT) and Cyadox (CYA) are important derivative of heterocyclic N-oxide quinoxaline (QdNO), used actively as antimicrobial feed additives in China. Here, we tested and compared the genotoxic potential of QCT and CYA with olaquindox (OLA) in Ames test, HGPRT gene mutation (HGM) test in V79 cells, unscheduled DNA synthesis (UDS) assay in human peripheral lymphocytes, chromosome aberration (CA) test, and...
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