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Article

Long-chain Acyl-CoA synthetase 4A regulates Smad activity and dorsoventral patterning in the zebrafish embryo.

Developmental cell - 23 Dec 2013

Miyares Rosa Linda, Stein Cornelia, Renisch Björn, Anderson Jennifer Lynn, Hammerschmidt Matthias, Farber Steven Arthur

Abstract excerpt

Long-chain polyunsaturated fatty acids (LC-PUFA) and their metabolites are critical players in cell biology and embryonic development. Here we show that long-chain acyl-CoA synthetase 4a (Acsl4a), an LC-PUFA activating enzyme, is essential for proper patterning of the zebrafish dorsoventral axis. Loss of Acsl4a results in dorsalized embryos due to attenuated bone morphogenetic protein (Bmp) signaling. We...

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Identifiers

PMID: 24332754
DOI: 10.1016/j.devcel.2013.11.011
PMCID: PMC3895552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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