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Article

CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression

27 Nov 2020

Abstract excerpt

Obesity drives the development of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis. Several bone morphogenetic proteins (BMPs) except BMP9 were reported related to metabolic syndrome. This study demonstrates that liver cytokine BMP9 is decreased in the liver and serum of NAFLD model mice and patients. BMP9 knockdown induces lipid accumulation in Hepa 1-6 cells. BMP9-knockout mice...

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PMID: 33246954
DOI: 10.1126/sciadv.abc5022

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