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Article

Using passenger mutations to estimate the timing of driver mutations and identify mutator alterations.

BMC bioinformatics - 13 Dec 2013

Youn Ahrim, Simon Richard

Abstract excerpt

BACKGROUND: Recent developments in high-throughput genomic technologies make it possible to have a comprehensive view of genomic alterations in tumors on a whole genome scale. Only a small number of somatic alterations detected in tumor genomes are driver alterations which drive tumorigenesis. Most of the somatic alterations are passengers that are neutral to tumor cell selection. Although most research efforts...

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Identifiers

PMID: 24330428
DOI: 10.1186/1471-2105-14-363
PMCID: PMC3903072

Genes

BRCA1
PRKDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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