Article
Highly resistant Salmonella enterica serovar Typhi with a novel gyrA mutation raises questions about the long-term efficacy of older fluoroquinolones for treating typhoid fever.
Antimicrobial agents and chemotherapy - 1 May 2012
Koirala Kanika Deshpande, Thanh Duy Pham, Thapa Sudeep Dhoj, Arjyal Amit, Karkey Abhilasha, Dongol Sabina, Shrestha Upendra Man, Farrar Jeremy J, Basnyat Buddha, Baker Stephen
Abstract excerpt
As a consequence of multidrug resistance, clinicians are highly dependent on fluoroquinolones for treating the serious systemic infection typhoid fever. While reduced susceptibility to fluoroquinolones, which lessens clinical efficacy, is becoming ubiquitous, comprehensive resistance is exception...
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