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Article

Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients

9 Dec 2013

Abstract excerpt

Circulating tumor cells (CTCs) enter peripheral blood from primary tumors and seed metastases. The genome sequencing of CTCs could offer noninvasive prognosis or even diagnosis, but has been hampered by low single-cell genome coverage of scarce CTCs. Here, we report the use of the recently developed multiple annealing and looping-based amplification cycles for whole-genome amplification of single CTCs from lung...

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PMID: 24324171
DOI: 10.1073/pnas.1320659110

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