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Article

Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese hamster ovary cells.

Biotechnology journal - 1 Apr 2014

Klanert Gerald, Jadhav Vaibhav, Chanoumidou Konstantina, Grillari Johannes, Borth Nicole, Hackl Matthias

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding RNAs (∼22 nucleotides) which regulate gene expression by silencing mRNA translation. MiRNAs are transcribed as long primary transcripts, which are enzymatically processed by Drosha/Dgcr8, in the nucleus, and by Dicer in the cytoplasm, into mature miRNAs. The importance of miRNAs for coordinated gene expression is commonly accepted. Consequentially, there is a growing...

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PMID: 24323929
DOI: 10.1002/biot.201300216
PMCID: PMC4282078

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