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Article

Stable overexpression of miR-17 enhances recombinant protein production of CHO cells.

Journal of biotechnology - 10 Apr 2014

Jadhav Vaibhav, Hackl Matthias, Klanert Gerald, Hernandez Bort Juan A, Kunert Renate, Grillari Johannes, Borth Nicole

Abstract excerpt

miRNAs negatively regulate gene expression at post-transcriptional level, and consequently play an important role in the control of many cellular pathways. The use of miRNAs to engineer Chinese hamster ovary (CHO) cells is an emerging strategy to improve recombinant protein production. Here, we d...

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Identifiers

PMID: 24518263
DOI: 10.1016/j.jbiotec.2014.01.032
PMCID: PMC3991393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24518263-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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