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The Effect of microRNA on the Production of Recombinant Protein in CHO Cells and its Mechanism

21 Mar 2022

Abstract excerpt

Recombinant protein production by mammalian cells is the initial step in the manufacture of many therapeutic proteins. Chinese hamster ovary (CHO) cells are the most common host system to produce recombinant therapeutic proteins (RTPs). However, it is still challenging to maintain high productivity ensuring the good quality of RTPs produced by CHO cells. MicroRNAs(miRNAs) are short regulatory non-coding RNAs that...

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PMID: 35387297
DOI: 10.3389/fbioe.2022.832065

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