Article
Control of specific gene expression in mammalian cells by co-expression of long complementary RNAs.
FEBS letters - 27 Aug 2004
Tran Nham, Raponi Mitch, Dawes Ian W, Arndt Greg M
Abstract excerpt
The use of long double-stranded RNA (dsRNA) for gene silencing in mammalian cells has generally been restricted to embryonic cell types and proposed to induce non-specific effects on gene expression in differentiated cells. In this study, we report that foreign and endogenous gene expression can be regulated in immortalised human cell lines by co-expression of long complementary RNAs with the potential to form...
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