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Article

Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell.

Scientific reports - 10 Dec 2013

Kakazu Eiji, Kondo Yasuteru, Kogure Takayuki, Ninomiya Masashi, Kimura Osamu, Ueno Yoshiyuki, Shimosegawa Tooru

Abstract excerpt

An imbalance of plasma amino acids (AA) is observed cirrhotic patients. Here we report that the imbalance suppresses the maturation of dendritic cells (DCs) by reducing the intracellular ATP due to interference with the mitochondrial tricarboxylic acid (TCA) cycle. We used serum-free culture medi...

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Identifiers

PMID: 24322372
DOI: 10.1038/srep03459
PMCID: PMC3857572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24322372-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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