Article
Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer.
Science advances - 31 May 2024
Drew David A, Kim Andre E, Lin Yi, Qu Conghui, Morrison John, Lewinger Juan Pablo, Kawaguchi Eric, Wang Jun, Fu Yubo, Zemlianskaia Natalia, Díez-Obrero Virginia, Bien Stephanie A, Dimou Niki, Albanes Demetrius, Baurley James W, Wu Anna H, Buchanan Daniel D, Potter John D, Prentice Ross L, Harlid Sophia, Arndt Volker, Barry Elizabeth L, Berndt Sonja I, Bouras Emmanouil, Brenner Hermann, Budiarto Arif, Burnett-Hartman Andrea, Campbell Peter T, Carreras-Torres Robert, Casey Graham, Chang-Claude Jenny, Conti David V, Devall Matthew A M, Figueiredo Jane C, Gruber Stephen B, Gsur Andrea, Gunter Marc J, Harrison Tabitha A, Hidaka Akihisa, Hoffmeister Michael, Huyghe Jeroen R, Jenkins Mark A, Jordahl Kristina M, Kundaje Anshul, Le Marchand Loic, Li Li, Lynch Brigid M, Murphy Neil, Nassir Rami, Newcomb Polly A, Newton Christina C, Obón-Santacana Mireia, Ogino Shuji, Ose Jennifer, Pai Rish K, Palmer Julie R, Papadimitriou Nikos, Pardamean Bens, Pellatt Andrew J, Peoples Anita R, Platz Elizabeth A, Rennert Gad, Ruiz-Narvaez Edward, Sakoda Lori C, Scacheri Peter C, Schmit Stephanie L, Schoen Robert E, Stern Mariana C, Su Yu-Ru, Thomas Duncan C, Tian Yu, Tsilidis Konstantinos K, Ulrich Cornelia M, Um Caroline Y, van Duijnhoven Fränzel J B, Van Guelpen Bethany, White Emily, Hsu Li, Moreno Victor, Peters Ulrike, Chan Andrew T, Gauderman W James
Abstract excerpt
Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular...
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