Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.

The Journal of clinical investigation - 1 Jan 2014

Jones Morgan, Osawa Gail, Regal Joshua A, Weinberg Daniel N, Taggart James, Kocak Hande, Friedman Ann, Ferguson David O, Keegan Catherine E, Maillard Ivan

Abstract excerpt

The shelterin complex plays dual functions in telomere homeostasis by recruiting telomerase and preventing the activation of a DNA damage response at telomeric ends. Somatic stem cells require telomerase activity, as evidenced by progressive stem cell loss leading to bone marrow failure in heredi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Caspase 7
Share to Chromosomal Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G2 Phase Cell Cycle Checkpoints

Share to Genes, Lethal

Share to Pancytopenia

Share to Telomere-Binding Proteins

Share to Telomere Shortening

Source

Open in PubMed Open full text

Identifiers

PMID: 24316971
DOI: 10.1172/JCI67871
PMCID: PMC3967656

Genes

TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24316971-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.PMID 24316971Read ↗

The role of telomere binding molecules for normal and abnormal hematopoiesis.Semantic proximity Read ↗

The shelterin complex and hematopoiesis.Semantic proximity Read ↗

Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita.Semantic proximity Read ↗

p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita.Semantic proximity Read ↗

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germlineSemantic proximity Read ↗

High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype.Semantic proximity Read ↗

Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1.Semantic proximity Read ↗

Essential roles for Pot1b in HSC self-renewal and survivalSemantic proximity Read ↗

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.Semantic proximity Read ↗

A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice.Semantic proximity Read ↗

Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1Semantic proximity Read ↗

Shelterin-Mediated Telomere ProtectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.