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Article

Shelterin-Mediated Telomere Protection

12 Sept 2018

Abstract excerpt

For more than a decade, it has been known that mammalian cells use shelterin to protect chromosome ends. Much progress has been made on the mechanism by which shelterin prevents telomeres from inadvertently activating DNA damage signaling and double-strand break (DSB) repair pathways. Shelterin averts activation of three DNA damage response enzymes [the ataxia-telangiectasia-mutated (ATM) and ataxia...

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PMID: 30208292
DOI: 10.1146/annurev-genet-032918-021921

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