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Article

In silico analysis of PFN1 related to amyotrophic lateral sclerosis

19 Jun 2019

Abstract excerpt

Profilin 1 (PFN1) protein plays key roles in neuronal growth and differentiation, membrane trafficking, and regulation of the actin cytoskeleton. Four natural variants of PFN1 were described as related to ALS, the most common adult-onset motor neuron disorder. However, the pathological mechanism of PFN1 in ALS is not yet completely understood. The goal of this work is to thoroughly analyze the effects of the...

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PMID: 31216283
DOI: 10.1371/journal.pone.0215723

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