Article
Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2.
Acta crystallographica. Section D, Biological crystallography - 1 Dec 2013
Horikoshi Naoki, Sato Koichi, Shimada Keisuke, Arimura Yasuhiro, Osakabe Akihisa, Tachiwana Hiroaki, Hayashi-Takanaka Yoko, Iwasaki Wakana, Kagawa Wataru, Harata Masahiko, Kimura Hiroshi, Kurumizaka Hitoshi
Abstract excerpt
The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. However, no structural differences between H2A.Z.1 and H2A.Z.2 have been reported. In the present study, the crystal structures of nucleosomes containing human H2A.Z.1 and H2A.Z.2 were determined. The structures...
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