Article
A polymorphism in the histone deacetylase 1 gene is associated with the response to corticosteroids in asthmatics.
The Korean journal of internal medicine - 1 Nov 2013
Kim Min-Hye, Kim Sae-Hoon, Kim Yook-Keun, Hong Soo-Jong, Min Kyung-Up, Cho Sang-Heon, Park Heung-Woo
Abstract excerpt
BACKGROUND/AIMS: Recent investigations suggest that histone deacetylase 1 (HDAC1) and HDAC2 may be target molecules to predict therapeutic responses to corticosteroids. We evaluated the effects of variation in HDAC1 and HDAC2 on the response to corticosteroids in asthmatics. METHODS: Two single nucleotide polymorphisms (SNPs) were selected after resequencing HDAC1 and HDAC2. For the first analysis, we evaluated...
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