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Article

Emerging roles and therapeutic implications of HDAC2 and IL-17A in steroid-resistant asthma

1 Jun 2023

Abstract excerpt

Steroid resistance represents a major clinical problem in the treatment of severe asthma, and therefore a better understanding of its pathogenesis is warranted. Recent studies indicated that histone deacetylase 2 (HDAC2) and interleukin 17A (IL-17A) play important roles in severe asthma. HDAC2 activity is reduced in patients with severe asthma and smoking-induced asthma, perhaps accounting for the amplified...

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PMID: 39170824
DOI: 10.1016/j.pccm.2023.04.003

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