<scp>IL</scp>‐4‐induced gene 1 maintains high <scp>T</scp>ob1 expression that contributes to <scp>TCR</scp> unresponsiveness in human <scp>T</scp> helper 17 cells

Abstract excerpt

Human Th17 cells have a limited proliferative capacity compared to other T-cell subsets. We have shown that human Th17 cells display impaired IL-2 production due to IL-4-induced gene 1 (IL4I1) upregulation. Here, we show that in human Th17 cells, IL4I1 also maintains high levels of Tob1, a member of the Tob/BTG (B-cell traslocation gene) antiproliferative protein family, which prevents cell-cycle progression...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related gene regulation
• Share to CAR-T cell therapy research