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Article

In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands.

The Journal of nutritional biochemistry - 1 Mar 2016

Govindarajah Vinothini, Leung Yuet-Kin, Ying Jun, Gear Robin, Bornschein Robert L, Medvedovic Mario, Ho Shuk-Mei

Abstract excerpt

Human studies suggest that high-fat diets (HFDs) increase the risk of breast cancer. The 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis rat model is commonly used to evaluate the effects of lifestyle factors such as HFD on mammary tumor risk. Past studies focused primarily on the effects of continuous maternal exposure on the risk of offspring at the end of puberty (PND50). We assessed the...

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Source

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Identifiers

PMID: 26895667
DOI: 10.1016/j.jnutbio.2015.11.003
PMCID: PMC4761409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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