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Article

Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels.

Genetics and molecular research : GMR - 29 Oct 2013

Liu N, Jiang J, Song Y J, Zhao S G, Tong Z G, Song H S, Wu H, Zhu J Y, Gu Y H, Sun Y, Hua W, Qi J P

Abstract excerpt

Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation. As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate folate...

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Source

Identifiers

PMID: 24301776
DOI: 10.4238/2013.October.29.10

Genes

MGMT
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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