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Article

BRAFV600E/pTERT double mutated papillary thyroid cancers exhibit immune gene suppression.

Frontiers in endocrinology - 1 Jan 2024

Sigarteu Chindris Ana-Maria, Rivera Michael, Ma Yaohua, Nair Asha, Liu Yi, Wang Xue, Necela Brian M, Kachergus Jennifer M, Casler John D, Brett Christopher, Rivas Mejia Ana M, Bernet Victor J, Copland John A, Knutson Keith L, Thompson E Aubrey, Smallridge Robert C

Abstract excerpt

Introduction: BRAFV600E mutation (BRAFmut) is common in papillary thyroid cancer (PTC), and most patients have an excellent outcome. However, a TERT-promoter mutation (pTERTmut) in the presence of BRAFmut (BRAFmutpTERTmut) has been demonstrated to confer a more aggressive behavior to PTC. Lymphocytic infiltration is often present in PTC. In this study, we sought to decipher the relationship between the BRAF and...

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Share to Aged
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins B-raf

Share to Telomerase

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

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Source

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Identifiers

PMID: 39717106
DOI: 10.3389/fendo.2024.1440722
PMCID: PMC11663634

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