Diagnostic accuracy in BRAF V600E-negative papillary thyroid cancer via 5-gene expression profiling of residual nucleic acids from mutation testing: a retrospective study.

Abstract excerpt

BACKGROUND: BRAF V600E mutation is insufficient for accurate diagnosis of thyroid neoplasms, although it has been widely used in clinical settings. We aimed to construct a messenger RNA (mRNA)-based model to identify thyroid cancer in indeterminate thyroid nodules in the absence of BRAF mutation. METHODS: Our cohort consisted of 88 papillary thyroid cancer (PTC) patients with BRAF V600E substitution, 103 BRAF...

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