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Article

ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers.

Molecular cancer research : MCR - 1 Jan 2014

Aisner Dara L, Nguyen Teresa T, Paskulin Diego D, Le Anh T, Haney Jerry, Schulte Nathan, Chionh Fiona, Hardingham Jenny, Mariadason John, Tebbutt Niall, Doebele Robert C, Weickhardt Andrew J, Varella-Garcia Marileila

Abstract excerpt

UNLABELLED: Activated anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinases, through gene fusions, have been found in lung adenocarcinomas and are highly sensitive to selective kinase inhibitors. This study aimed at identifying the presence of these rearrangements in human colorectal adenoca...

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Source

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Identifiers

PMID: 24296758
DOI: 10.1158/1541-7786.MCR-13-0479-T
PMCID: PMC4140177

Genes

ALK
ROS1
BRAF
EML4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24296758-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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