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Article

ROS1 immunohistochemistry for detection of ROS1-rearranged lung adenocarcinomas.

The American journal of surgical pathology - 1 Sept 2013

Sholl Lynette M, Sun Heather, Butaney Mohit, Zhang Chengsheng, Lee Charles, Jänne Pasi A, Rodig Scott J

Abstract excerpt

ROS1 gene rearrangements are reported in 1% to 2% of lung adenocarcinomas (ACAs) and are associated with response to the multitargeted tyrosine kinase inhibitor crizotinib. ROS1 rearrangements can be detected using fluorescence in situ hybridization (FISH); however, immunohistochemistry (IHC) for ROS1 protein is a promising alternate screening modality. In this study, we examine the correlation between ROS1 IHC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23887156
DOI: 10.1097/PAS.0b013e3182960fa7
PMCID: PMC3831351

Genes

ROS1
ALK
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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