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Article

ROS1 immunohistochemistry among major genotypes of non-small-cell lung cancer.

Clinical lung cancer - 1 Mar 2015

Boyle Theresa A, Masago Katsuhiro, Ellison Kim E, Yatabe Yasushi, Hirsch Fred R

Abstract excerpt

BACKGROUND: ROS1 gene fusions cause several cancers by constitutively activating the ROS1 tyrosine kinase receptor. ROS1-targeted inhibitor therapy improves survival in the approximately 1% to 2% of patients with lung adenocarcinoma with ROS1 gene fusions. Although fluorescence in situ hybridization (FISH) is the standard diagnostic procedure for detecting ROS1 rearrangements, we studied immunohistochemistry...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25467930
DOI: 10.1016/j.cllc.2014.10.003
PMCID: PMC4770803

Genes

ROS1
ALK
EGFR
ERBB2
KRAS
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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