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Article

Identification of ROS1 rearrangement in gastric adenocarcinoma

7 Feb 2013

Abstract excerpt

BACKGROUND: Recently, chromosomal rearrangements involving receptor tyrosine kinases (RTKs) have been described in common epithelial malignancies, including nonsmall cell lung cancer (NSCLC), colorectal cancer, and breast cancer. One of these RTKs, c-ros oncogene 1, receptor tyrosine kinase (ROS1), has been identified as a driver mutation in NSCLC, because its inhibition by crizotinib, an anaplastic lymphoma...

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PMID: 23400546
DOI: 10.1002/cncr.27967

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