Article
Concurrent ROS1 gene rearrangement and KRAS mutation in lung adenocarcinoma: A case report and literature review.
Thoracic cancer - 1 Jan 2018
Zhu You-Cai, Lin Xue-Ping, Li Xiao-Feng, Wu Li-Xin, Chen Hua-Fei, Wang Wen-Xian, Xu Chun-Wei, Shen Jian-Fa, Wei Jian-Guo, Du Kai-Qi
Abstract excerpt
Lung adenocarcinomas with gene rearrangement in the receptor tyrosine kinase ROS1 have emerged as a rare molecular subtype. Although these lung adenocarcinomas respond to ROS1tyrosine kinase inhibitors, many patients ultimately acquire resistance. ROS1gene rearrangement is generally mutually excl...
Topics
- Adenocarcinoma
- Adenocarcinoma of Lung
- Adult
- Humans
- Lung Neoplasms
- Male
- Mutation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- ras Proteins