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Article

ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non-Small Cell Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2017

Lin Jessica J, Ritterhouse Lauren L, Ali Siraj M, Bailey Mark, Schrock Alexa B, Gainor Justin F, Ferris Lorin A, Mino-Kenudson Mari, Miller Vincent A, Iafrate Anthony J, Lennerz Jochen K, Shaw Alice T

Abstract excerpt

INTRODUCTION: Chromosomal rearrangements involving the gene ROS1 define a distinct molecular subset of NSCLCs with sensitivity to ROS1 inhibitors. Recent reports have suggested a significant overlap between ROS1 fusions and other oncogenic driver alterations, including mutations in EGFR and KRAS. METHODS: We identified patients at our institution with ROS1-rearranged NSCLC who had undergone testing for genetic...

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Identifiers

PMID: 28088512
DOI: 10.1016/j.jtho.2017.01.004
PMCID: PMC5403618

Genes

ROS1
KRAS
EGFR
ALK
AKT1
BRAF
ERBB2

Variants

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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