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ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer

22 Aug 2022

Abstract excerpt

c-Ros oncogene 1, receptor tyrosine kinase (ROS1) genomic rearrangements have been reported previously in rare cases of colorectal cancer (CRC), yet little is known about the frequency, molecular characteristics, and therapeutic vulnerabilities of ROS1-driven CRC. We analyzed a clinical dataset of 40 589 patients with CRC for ROS1 genomic rearrangements and their associated genomic characteristics (Foundation...

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PMID: 36053834
DOI: 10.1002/ijc.34257

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