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Testing for ROS1 in non-small cell lung cancer: a review with recommendations

17 Aug 2016

Abstract excerpt

Rearrangements of the ROS1 gene occur in 1-2 % of non-small cell lung cancers (NSCLCs). Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the treatment of patients with advanced ROS1-positive NSCLC. Consequently, focus on ROS1 testing is growing. Most laboratories currently rely on fluorescence in situ hybridisation (FISH) assays using a dual-colour break-apart probe to...

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PMID: 27535289
DOI: 10.1007/s00428-016-2000-3

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