Article
High Prevalence of Concomitant Oncogene Mutations in Prospectively Identified Patients with ROS1-Positive Metastatic Lung Cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2017
Wiesweg Marcel, Eberhardt Wilfried E E, Reis Henning, Ting Saskia, Savvidou Nikoleta, Skiba Charlotte, Herold Thomas, Christoph Daniel C, Meiler Johannes, Worm Karl, Kasper Stefan, Theegarten Dirk, Hense Jörg, Hager Thomas, Darwiche Kaid, Oezkan Filiz, Aigner Clemens, Welter Stefan, Kühl Hilmar, Stuschke Martin, Schmid Kurt W, Schuler Martin
Abstract excerpt
OBJECTIVES: Chromosomal rearrangements involving ROS1 define a rare entity of lung adenocarcinomas with exquisite sensitivity to molecularly targeted therapy. We report clinical outcomes and genomic findings of patients with ROS1-positive lung cancer who were prospectively identified within a multiplex biomarker profiling program at the West German Cancer Center. METHODS: Standardized immunohistochemical (IHC)...
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