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Article

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer.

Oncotarget - 6 Oct 2015

Jones Dominic, Wade Mark, Nakjang Sirintra, Chaytor Lewis, Grey James, Robson Craig N, Gaughan Luke

Abstract excerpt

Retention of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the requirement for the development of more effective AR targeting therapies. A key mechanism of resistance to anti-androgens is through expression of constitutively active AR variants (AR-Vs) that are refractory to next-generation therapies, including Enzalutamide and Abiraterone. By maintaining an androgenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26336819
DOI: 10.18632/oncotarget.4927
PMCID: PMC4745762

Genes

FOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer.PMID 26336819Read ↗

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