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Article

Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory.

Nature neuroscience - 1 Jan 2014

Liu Bingfang, Zupan Bojana, Laird Emma, Klein Shifra, Gleason Georgia, Bozinoski Marjan, Gal Toth Judit, Toth Miklos

Abstract excerpt

Tumor necrosis factor α (TNF) is a proinflammatory cytokine with established roles in host defense and immune system organogenesis. We studied TNF function and found a previously unidentified physiological function that extends its effect beyond the host into the developing offspring. A partial or complete maternal TNF deficit, specifically in hematopoietic cells, resulted in reduced milk levels of the chemokines...

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Identifiers

PMID: 24292233
DOI: 10.1038/nn.3596
PMCID: PMC6169993

Genes

TNF
MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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