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Article

In utero Exposure to Maternal Chronic Inflammation Transfers a Pro-Inflammatory Profile to Generation F2 via Sex-Specific Mechanisms.

Frontiers in immunology - 1 Jan 2020

Adams Rozanne Charlene McChary, Smith Carine

Abstract excerpt

Generational transfer of maladaptations in offspring have been reported to persist for multiple generations in conditions of chronic inflammation, metabolic and psychological stress. Thus, the current study aimed to expand our understanding of the nature, potential sex specificity, and transgenerational plasticity of inflammatory maladaptations resulting from maternal chronic inflammation. Briefly, F1 and F2...

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Identifiers

PMID: 32117231
DOI: 10.3389/fimmu.2020.00048
PMCID: PMC7031653

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