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Article

Pharmacoperones and the calcium sensing receptor: exogenous and endogenous regulators.

Pharmacological research - 1 May 2014

Breitwieser Gerda E

Abstract excerpt

Calcium sensing receptor (CaSR) mutations or altered expression cause disorders of calcium handling. Recent studies suggest that reduced targeting to the plasma membrane is a feature common to many CaSR loss-of-function mutations. Allosteric agonists (calcimimetics) can rescue signaling of a subset of CaSR mutants. This review evaluates our current understanding of the subcellular site(s) for allosteric modulator...

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Identifiers

PMID: 24291533
DOI: 10.1016/j.phrs.2013.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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