Article
Characterization of elements involved in allosteric light regulation of phosphodiesterase activity by comparison of different functional BlrP1 states.
Journal of molecular biology - 20 Feb 2014
Winkler Andreas, Udvarhelyi Anikó, Hartmann Elisabeth, Reinstein Jochen, Menzel Andreas, Shoeman Robert L, Schlichting Ilme
Abstract excerpt
Bacteria have evolved dedicated signaling mechanisms that enable the integration of a range of environmental stimuli and the accordant modulation of metabolic pathways. One central signaling molecule in bacteria is the second messenger cyclic dimeric GMP (c-di-GMP). Complex regulatory mechanisms for modulating c-di-GMP concentrations have evolved, in line with its importance for maintaining bacterial fitness...
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