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Article

Cancer risks associated with the germline MITF(E318K) variant.

Scientific reports - 13 Oct 2020

Guhan Samantha M, Artomov Mykyta, McCormick Shelley, Njauw Ching -Ni, Stratigos Alexander J, Shannon Kristen, Ellisen Leif W, Tsao Hensin

Abstract excerpt

The MITF(E318K) variant confers moderate risk for cutaneous melanoma. While there are small studies suggesting that this risk is associated with other malignancies (e.g. renal cell carcinoma), little is known about the role of this variant in specifying risk for other cancers. In this study, we perform a systematic review and meta-analysis of the published data as a backdrop to a whole-exome sequence(WES)-based...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Germ-Line Mutation

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Share to Melanoma, Cutaneous Malignant

Share to Microphthalmia-Associated Transcription Factor

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Source

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Identifiers

PMID: 33051548
DOI: 10.1038/s41598-020-74237-z
PMCID: PMC7555480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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