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Article

Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects.

The Journal of biological chemistry - 29 Oct 1999

Zhou Z, Gong Q, January C T

Abstract excerpt

The chromosome 7-linked form of congenital long QT syndrome (LQT2) is caused by mutations in the human ether-a-go-go-related gene (HERG) that encodes the rapidly activating delayed rectifier potassium channel. One mechanism for the loss of normal channel function in LQT2 is defective protein trafficking, which results in the failure of the channel protein to reach the plasma membrane. Here we show that the N470D...

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Identifiers

PMID: 10531299
DOI: 10.1074/jbc.274.44.31123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects.PMID 10531299Read ↗

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Rescue of mutated cardiac ion channels in inherited arrhythmia syndromes.Semantic proximity Read ↗

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