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Article

Structural Insights into the Mechanism of Base Excision by MBD4.

Journal of molecular biology - 23 Jul 2021

Pidugu Lakshmi S, Bright Hilary, Lin Wen-Jen, Majumdar Chandrima, Van Ostrand Robert P, David Sheila S, Pozharski Edwin, Drohat Alexander C

Abstract excerpt

DNA glycosylases remove damaged or modified nucleobases by cleaving the N-glycosyl bond and the correct nucleotide is restored through subsequent base excision repair. In addition to excising threatening lesions, DNA glycosylases contribute to epigenetic regulation by mediating DNA demethylation and perform other important functions. However, the catalytic mechanism remains poorly defined for many glycosylases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34107280
DOI: 10.1016/j.jmb.2021.167097
PMCID: PMC8286355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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