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GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells.

Diabetes - 1 Mar 2018

Villamayor Laura, Rodríguez-Seguel Elisa, Araujo Raquel, Carrasco Manuel, Bru-Tarí Eva, Mellado-Gil José Manuel, Gauthier Benoit R, Martinelli Paola, Quesada Iván, Soria Bernat, Martín Franz, Cano David A, Rojas Anabel

Abstract excerpt

GATA4 and GATA6 play essential, but redundant, roles in pancreas formation in mice, and GATA6 mutations cause pancreatic agenesis in humans. GATA6 mutations have also recently been linked to adult-onset diabetes, with subclinical or no exocrine insufficiency, suggesting an important role for GATA6 in human β-cell physiology. To investigate the role of GATA6 in the adult endocrine pancreas, we generated mice in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29263149
DOI: 10.2337/db17-0364

Genes

GATA6
GATA4

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