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Article

GATA4 mutations are a cause of neonatal and childhood-onset diabetes.

Diabetes - 1 Aug 2014

Shaw-Smith Charles, De Franco Elisa, Lango Allen Hana, Batlle Marta, Flanagan Sarah E, Borowiec Maciej, Taplin Craig E, van Alfen-van der Velden Janiëlle, Cruz-Rojo Jaime, Perez de Nanclares Guiomar, Miedzybrodzka Zosia, Deja Grazyna, Wlodarska Iwona, Mlynarski Wojciech, Ferrer Jorge, Hattersley Andrew T, Ellard Sian

Abstract excerpt

The GATA family zinc finger transcription factors GATA4 and GATA6 are known to play important roles in the development of the pancreas. In mice, both Gata4 and Gata6 are required for pancreatic development. In humans, GATA6 haploinsufficiency can cause pancreatic agenesis and heart defects. Congenital heart defects also are common in patients with GATA4 mutations and deletions, but the role of GATA4 in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24696446
DOI: 10.2337/db14-0061
PMCID: PMC6850908

Genes

GATA4
GATA6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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GATA4 mutations are a cause of neonatal and childhood-onset diabetes.PMID 24696446Read ↗

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