Targeted knock-in of the polymorphism rs61764370 does not affect KRAS expression but reduces let-7 levels.

doi:10.1002/humu.22487

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Article

Targeted knock-in of the polymorphism rs61764370 does not affect KRAS expression but reduces let-7 levels.

Human mutation - 1 Feb 2014

Crowley Emily Hannah, Arena Sabrina, Lamba Simona, Di Nicolantonio Federica, Bardelli Alberto

Abstract excerpt

Understanding the role of single-nucleotide polymorphisms (SNPs) in the pathological process represents a unique experimental challenge especially when the variants occur outside of coding regions. The noncoding SNP rs61764370 located in the 3'-untranslated region of Kirsten rat sarcoma viral oncogene homolog (KRAS) has been implicated as a risk factor for the development of cancer and the response to targeted...

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PMID: 24282149
DOI: 10.1002/humu.22487

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