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Article

TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cells.

PloS one - 1 Jan 2013

Luu Carrie, Heinrich Eileen L, Duldulao Marjun, Arrington Amanda K, Fakih Marwan, Garcia-Aguilar Julio, Kim Joseph

Abstract excerpt

Recent reports have indicated that KRAS and TP53 mutations predict response to therapy in colorectal cancer. However, little is known about the relationship between these two common genetic alterations. Micro-RNAs (miRNAs), a class of noncoding RNA implicated in cellular processes, have been increasingly linked to KRAS and TP53. We hypothesized that lethal-7a (let-7a) miRNA regulates KRAS through TP53. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23936455
DOI: 10.1371/journal.pone.0070604
PMCID: PMC3731270

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cells.PMID 23936455Read ↗

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