The impact of genes on the occurrence of autoantibodies in rheumatoid arthritis. A study on disease discordant twin pairs.

doi:10.1016/j.jaut.2012.12.001

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Article

The impact of genes on the occurrence of autoantibodies in rheumatoid arthritis. A study on disease discordant twin pairs.

Journal of autoimmunity - 1 Mar 2013

Svendsen Anders J, Hjelmborg Jacob V, Kyvik Kirsten O, Houen Gunnar, Nielsen Christian, Skytthe Axel, Junker Peter

Abstract excerpt

OBJECTIVE: To assess the genetic effect on the occurrence of rheumatoid arthritis (RA) associated autoantibodies. METHODS: A co-twin control study of 27 monozygotic (MZ) and 51 dizygotic same sexed (DZss) RA discordant twins. OUTCOME MEASURES: The probandwise concordance rate of anti-keratin antibodies (AKA), anti-cyclic citrullinated peptide antibodies (ACPA), IgA- and IgM rheumatoid factor (IgA-RF and IgM-RF)....

Topics

Aged
Alleles
Arthritis, Rheumatoid
Autoantibodies
Diseases in Twins
Female
Genetic Predisposition to Disease
Genotype
HLA-DRB1 Chains
Humans
Keratins
Logistic Models
Male
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multivariate Analysis

Peptides, Cyclic

Polymorphism, Single Nucleotide

Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Open in PubMed

Identifiers

PMID: 23290888
DOI: 10.1016/j.jaut.2012.12.001

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.