Article
The impact of genes on the occurrence of autoantibodies in rheumatoid arthritis. A study on disease discordant twin pairs.
Journal of autoimmunity - 1 Mar 2013
Svendsen Anders J, Hjelmborg Jacob V, Kyvik Kirsten O, Houen Gunnar, Nielsen Christian, Skytthe Axel, Junker Peter
Abstract excerpt
OBJECTIVE: To assess the genetic effect on the occurrence of rheumatoid arthritis (RA) associated autoantibodies. METHODS: A co-twin control study of 27 monozygotic (MZ) and 51 dizygotic same sexed (DZss) RA discordant twins. OUTCOME MEASURES: The probandwise concordance rate of anti-keratin antibodies (AKA), anti-cyclic citrullinated peptide antibodies (ACPA), IgA- and IgM rheumatoid factor (IgA-RF and IgM-RF)....
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