Article
Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population.
Arthritis and rheumatism - 1 Sept 2009
Morgan Ann W, Thomson Wendy, Martin Stephen G, Carter Angela M, Erlich Henry A, Barton Anne, Hocking Lynne, Reid David M, Harrison Pille, Wordsworth Paul, Steer Sophia, Worthington Jane, Emery Paul, Wilson Anthony G, Barrett Jennifer H
Abstract excerpt
OBJECTIVE: To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, and smoking in cyclic citrullinated peptide (CCP) antibody- and rheumatoid factor (RF)-positive and -negative rheumatoid arthritis (RA). METHODS: Data on approximately 5,000 RA patients and approximately 3,700 healthy controls recruited from 6 centers in the UK were analyzed; not all centers had both genotype data and smoking data...
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