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Article

Beneficial and Detrimental Roles of NLRs in Carcinogenesis

1 Jan 2013

Abstract excerpt

Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic mutations, tumor promotion, and angiogenesis. Tumor-promoting inflammation is driven by many factors including the presence of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. One major source of IL-1β and IL-18 secretion is through the activation of inflammasomes. Inflammasomes are multi-protein complexes that upon...

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Identifiers

PMID: 24273542
DOI: 10.3389/fimmu.2013.00370

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